Novel Polymer Encoding Methods
| Team | Chem | Info | In vivo |
|---|---|---|---|
| CatalogDNA | - | Info | N |
| Centrilliontech | Chem+Enz | Imaging | N |
| DNAScript | - | - | N |
| Dodo_Omnidata | - | Info | N |
| Evonetix | - | Bio | N |
| Glotta Tech | TdT | Info | N |
| Kalhor et al. 2017 | Cas9 | Info | Y |
| Microsoft | Chem | Info | N |
| Molecular Assemblies | TdT | Bio+Info | N |
| Nuclera | - | - | N |
| Shipman et al. 2017 | Cas1/2 | Info | Y |
| Technicolor | Chem | Info | N |
| Twist | Chem | Bio+Info | N |
Chem: Phosphoramidite, water-free acetonitrile, etc.
Enz: Enzymatic Polymerization (PNP, TdT, ligase, etc.)
TdT: Terminal deoxynucleotidyl Transferase
Bio: High fidelity required for biological applications
Info: Lower raw accuracy, yet high consensus accuracy
Imaging: In situ sequencing in fixed tissue sections
In situ: applications to recording biological data in living cells